TGF-β1 cotreated with OM led to a milder up-regulation of miR-378a-3p during the early (Figure 3C) and mature phases (Figure 3E) of calcification, and also a milder up-regulation of CTGF during the early (Figure 3F), mid-term (Figure 3G), and mature phases (Figure 3H) of calcification. Here, CCN2 is linked to ocular melanoma.