Genetic investigation identified a series of susceptibility loci for AMD in innate immunity–related genes, such as complement factor H (CFH), complement C2 (C2), complement C3 (C3), Toll-like receptor 4 (TLR4), and C-X3-C motif chemokine receptor 1 (CX3CR1). The gene discussed is C2; the disease is age-related macular degeneration.