There were no significant differences in emphysema or SAF according to sex (Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.130771DS1) or in respiratory mechanics between CS-exposed and rhCC16-treated and CS-exposed and vehicle-treated WT or Cc16–/– mice (Supplemental Table 2). This evidence concerns the gene SCGB1A1 and pulmonary emphysema.