Furthermore, in patients with systolic or diastolic dysfunction, cardiac interstitial fibrosis was associated with low miR-221/222 levels; in a mouse model of angiotensin II–induced cardiac remodeling and heart failure, the inhibition of miR-221/222 was able to promote cardiac interstitial fibrosis, cardiac dilation, and dysfunction (37). The gene discussed is AGT; the disease is Interstitial cardiac fibrosis.