While body weight–related parameters (e.g., final body weight gain, lean mass, and fat mass) were affected to a similar extent in PWK/PhJ, C57BL/6J, DBA/2J, and 129S1/SvlmJ strains, PWK/PhJ mice showed more severe insulin resistance and worsened liver damage–related phenotypes like liver weight and plasma ALAT and aspartate aminotransferase (ASAT) levels (Fig. 2 D and Fig. S1, F–M). The gene discussed is ABCB7; the disease is Insulin resistance.