COL4A1 and ischemic stroke: Here, we (1) investigate the co-segregation of the causative COL4A1 variant in the original PADMAL family complementing published clinical and radiological [4, 24] as well as pathological data [3, 4, 25] of this family and, and describe the clinical and radiological presentation and progression of PADMAL using this family and literature data (2) report a sequence analysis of the mutated miRNA-29-binding site in two German samples of patients with sporadic cerebral microangiopathies as well as other types of ischemic stroke.