The second purpose of this manuscript is to answer the question of whether some sporadic stroke patients also show a variant in the COL4A1 miRNA-29-binding site, we sequenced 874 German stroke patients, of whom 291 suffered from a microangiopathic stroke but did not find a single variant in the COL4A1 miRNA-29-binding site. The gene discussed is COL4A1; the disease is Stroke.