MRC1 and neoplasm: Following this analogy, we hypothesized that IL-33 favors AE, as it has been demonstrated in several tumor models that IL-33 is associated with a pro-tumorigenic microenvironment, especially through the accumulation of M2-like (CD206+) tumor-associated macrophages (24, –, 26), but also enhancing the activity of the Tregs Th2 and ILC2 (27, 28).