In contrast, in primary normal human astrocytes, inhibitors of PI3K, AKT, and mTOR, including wortmannin (PI3K), MK2206 (AKT), and rapamycin (mTOR), inhibit JCPyV infection while MAPK-ERK inhibitors like U0126 fail to reduce infection (25). The gene discussed is MTOR; the disease is infection.