In tauopathies such as Alzheimer’s disease (AD),aberrantphosphorylation causes the dissociation of tau proteins from microtubules.The dissociated tau then aggregates into sequent forms from solubleoligomers to paired helical filaments and insoluble neurofibrillarytangles (NFTs). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.