In summary, except for demonstrating that EA can activate the VEGF/Notch signaling pathway to promote angiogenesis after focal CIRI, the more important discovery is that EA can reduce the pathological changes of edema, necrosis, and apoptosis by regulating the morphological changes of ECs and promoting the recovery of neurological function after ischemic stroke. The gene discussed is VEGFA; the disease is ischemic stroke.