1994). Glucose transporters can form a feedback mechanism with Runx2 in osteoblast cell lines, determining the onset of osteoblast differentiation during embryonic development and bone formation and reconstruction throughout the life cycle (Lee et al. 2017). A previous study showed that MOR improved high glucose-induced osteogenic differentiation and alleviated bone loss in a diabetic OP model via the activation of the Glo1pathway (Sun et al. 2020). The gene discussed is RUNX2; the disease is diabetes mellitus.