It has been observed that exosomes derived from renal cell carcinoma (RCC) cells are enriched with carbonic anhydrase 9 (CA9), a downstream target of HIF‐α, and promote human umbilical vein endothelial cell (HUVEC) migration and tube formation through CA9‐mediated MMP‐2 upregulation.56 Here, MMP2 is linked to renal cell carcinoma.