It has been observed that exosomes derived from renal cell carcinoma (RCC) cells are enriched with carbonic anhydrase 9 (CA9), a downstream target of HIF‐α, and promote human umbilical vein endothelial cell (HUVEC) migration and tube formation through CA9‐mediated MMP‐2 upregulation.56 This evidence concerns the gene CA9 and hereditary clear cell renal cell carcinoma.