We found that the expression levels of CDKAL1 were increased in the population of CSCs and demonstrated that CDKAL1 was required for the maintenance of CSCs‐related traits in RMS as well as the other common cancers, such as melanoma, liver cancer, prostate cancer, stomach cancer, and glioma (Figures 1 and 2 and Figures S1–S5, Supporting Information). The gene discussed is CDKAL1; the disease is central nervous system cancer.