We also confirmed that the CDKAL1 deficit induced differentiation, as shown by the loss of CD133 and the gain of myosin heavy chain (MyHC) both in vitro and in vivo (Figure 2D,E,G), and attenuated the tumor‐propagating potential of RMS‐YM cells in immunocompromised mice (Figure 2F). This evidence concerns the gene MYH6 and neoplasm.