CDKAL1 and cancer: YAP1 is essential for maintaining CSCs and a cause of poor prognosis in many cancers, including RMS.[43, 44, 45] CDKAL1 deficit does not induce a global loss of protein synthesis but attenuates the translation of selective mRNAs, including the CSC factors, such as SALL2 and YAP1, and thus may synergistically inhibit the CSC properties.