YAP1 is essential for maintaining CSCs and a cause of poor prognosis in many cancers, including RMS.[43, 44, 45] CDKAL1 deficit does not induce a global loss of protein synthesis but attenuates the translation of selective mRNAs, including the CSC factors, such as SALL2 and YAP1, and thus may synergistically inhibit the CSC properties. This evidence concerns the gene YAP1 and cancer.