CDKAL1 and rhabdomyosarcoma: Rhabdomyosarcoma (RMS) is a rare but most common malignant soft tissue tumor in young children.[22] Although recent advances in integrative and comprehensive treatment have improved patient survival, the prognosis of patients with metastases or recurrence remains poor, probably due to the CSC population.[23, 24, 25] Here, we find that the expression levels of CDKAL1, a member of the methylthiotransferase family that has been associated with susceptibility to type II diabetes,[26, 27, 28, 29] are significantly elevated in a CSC population of RMS cells.