We observed a positive relationship between individuals’ hs-CRP (HR 1.91, 95% CI 1.42–2.55, p = 1.51×10−5) and TNF-α (HR 1.43, 95% CI 1.05–1.96, p = 2.46×10−2) levels, and increased risk of CHD event (Appendix 1—table 2). This evidence concerns the gene TNF and coronary artery disorder.