Inhibition of TLR4 not only alleviated the severity of experimental arthritis and suppressed IL-1β expression in arthritic joints of CIA mice [63] but also ameliorated inflammatory symptoms in adjuvant-induced arthritis (AIA) rat model and inhibited the secretion of IL-6 and IL-8 in both serum of the AIA rats and human synovial fibroblasts [64]. Here, IL6 is linked to arthritic joint disease.