Briefly, the overexpression of FOXM1 enhanced RCC cell aggressiveness and FOXM1 could be regulated by various ncRNAs such as lncRNA and miRNA, while the overexpression of PLG might inhibit the proliferation and metastasis of ccRCC (Jiang et al., 2021; Okato et al., 2017; Wu et al., 2021). The gene discussed is FOXM1; the disease is renal cell adenocarcinoma.