Neuromodulin U (NMU) activates the G protein-coupled receptor NMUR2, and NMU signaling interacts with several cancer-related pathways, including the WNT receptor cascade, resulting in increased activation of WNT/planar cell polarity (PCP) effector RAC1, which promotes tumor cell invasion and metastasis [22]. The gene discussed is NMUR2; the disease is neoplasm.