For example, among the most significantly enriched phenotypes were abnormal circulating insulin levels, and abnormal glucose tolerance for Type 2 diabetes, abnormal systemic arterial blood pressure for hypertension, abnormal CD4-positive, alpha-beta T cell physiology and abnormal T-helper 2 physiology for asthma, abnormal hepatobiliary system physiology for coronary artery disease, decreased cholesterol level and decreased circulating cholesterol level for hyperlipidemia and abnormal skin pigmentation for skin cancer. This evidence concerns the gene CD4 and skin neoplasm.