INS and type 2 diabetes mellitus: For example, among the most significantly enriched phenotypes were abnormal circulating insulin levels, and abnormal glucose tolerance for Type 2 diabetes, abnormal systemic arterial blood pressure for hypertension, abnormal CD4-positive, alpha-beta T cell physiology and abnormal T-helper 2 physiology for asthma, abnormal hepatobiliary system physiology for coronary artery disease, decreased cholesterol level and decreased circulating cholesterol level for hyperlipidemia and abnormal skin pigmentation for skin cancer.