Although it is a challenging task to prove that the prioritized genes from any method are indeed causal, we show multiple lines of evidence from mouse phenotype data, curated gold-standard gene lists, mutation rate data and supporting literature that BIGKnock is helpful in identifying putative causal genes including several examples with known causal links in the literature such as ASGR1 and ANGPTL4 and cholesterol, and ALDH2 and coronary artery disease. The gene discussed is ANGPTL4; the disease is coronary artery disorder.