Gene-set variation analysis (GSVA) enrichment analysis showed that compared with the B subtype, m7G subtype A was significantly enriched in immune fully-activated pathways, including primary immunodeficiency, autoimmune thyroid disease, graft versus host disease, allograft rejection, intestinal immune network for IgA production, and asthma (Fig. 7A). The gene discussed is CD79A; the disease is asthma.