Gene-set variation analysis (GSVA) enrichment analysis showed that compared with the B subtype, m7G subtype A was significantly enriched in immune fully-activated pathways, including primary immunodeficiency, autoimmune thyroid disease, graft versus host disease, allograft rejection, intestinal immune network for IgA production, and asthma (Fig. 7A). Here, CD79A is linked to inborn error of immunity.