CHIT1 and tuberculosis: However, elevated chitotriosidase activity also occurs in other lysosomal storage disorders and inflammatory processes (i.e., tuberculosis, sarcoidosis, and β-thalassemia, Krabbe disease, GM1 gangliosidosis, Nieman-Pick disease) due to macrophage activation, which compromises its specificity, although chitotriosidase levels are highest in GD patients [22–24].