Dong et al. showed that a GC-associated tRF tRF-24-V29K9UV3IU impeded GC progression through regulating the Wnt signaling pathway [125], while Zhu and coworkers indicated the inhibition of tRF-5026a on GC progression was associated with the PTEN/PI3K/AKT signaling pathway [99]. The gene discussed is AKT1; the disease is gastric cancer.