OSA-related intermittent hypoxia, neuroinflammation and sleep fragmentation have been proven to accelerate neurodegeneration by disturbing Aβ clearance and aggravating neurofibrillary tangles of tau in AD [134], or by damaging the nigrostriatal dopaminergic system and promoting aggregation of α-synuclein in PD [135]. Here, MAPT is linked to Alzheimer disease.