MAPT and Alzheimer disease: Sleep deprivation or disruption significantly increases neuroinflammation and subsequent Aβ production in the cerebrospinal fluid (CSF) of AD patients [103], increases Aβ and phosphorylated tau (ptau) levels in transgenic AD mouse models [104, 105], and decreases glymphatic flow and Aβ clearance in human CSF and in animal models [104, 106], which may lead to further progression of neurodegeneration in AD.