Moreover, the participants in the lowest quartile of fasting BDNF were more likely to be older (P value for trend  < 0.001) and male (P value for trend = 0.023) and to have hypertension (P value for trend = 0.007), reduced BMI (P value for trend = 0.014), reduced diastolic blood pressure (P value for trend = 0.001), increased UACR (P value for trend = 0.009), increased CRP (P value for trend  < 0.001), decreased total cholesterol (P value for trend = 0.005), and decreased triglycerides (P value for trend  < 0.001). The gene discussed is BDNF; the disease is Hypertension.