Interestingly, since TrkB inhibition was shown to induce podocyte dedifferentiation and a strong correlation was detected between mRNA levels of BDNF in the urine cells and various indicators of kidney injury in CKD patients, it was suggested that BDNF in urine cells could serve as a biomarker of CKD [41]. This evidence concerns the gene NTRK2 and urogenital neoplasm.