There was no significant difference in the detection rate of EBV IgM antibody between active and stable SLE patients (χ2 = 0.442, P = 0.506), among which 14 patients with active SLE were positive, and the positive rate was 25.45%, which was significantly different from that of the control group (χ2 = 26.73, P = 0). The gene discussed is CD40LG; the disease is systemic lupus erythematosus.