Jiang et al. [77] found that AOM/DSS-induced colitis-associated CRC (CAC) mice showed downregulation of p65 and p-STAT3 expression in colonic tissues and downregulation of interleukin 6 (IL-6), p65, and p-STAT3 expression in serum after WMW intervention. The gene discussed is RELA; the disease is infectious otitis media.