MMP9 and colorectal carcinoma: Chen et al. [74] found that BBR reversed the upregulated protein expression of Ki-67 and β-catenin; downregulated the expression of interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α), NF-κB, matrix metallopeptidase 9 (MMP9), Ereg, and Muc16 in AMO/DSS model mice; and regulated cell proliferation, angiogenesis, and invasion through the NF-κB signaling pathway by exerting anti-CRC effects.