Sun et al. [57] found that the expression of hypoxia-inducible factor-1α (HIF-1α), PI3K, Akt/p-Akt, hexokinase II, and glucose transporter type 1 (GLUT1) was downregulated and that of caspase-3 and -9 was upregulated in 5-FU-resistant human CRC cells (HCT-8/5-FU) after the intervention of Jiedu Sangen decoction (JSD). The gene discussed is AKT1; the disease is colorectal carcinoma.