TCM could regulate multiplesignaling pathways related to CRC progression, including PI3K/Akt, NF-κB, MAPK, Wnt/β-catenin, EGFR, p53, TGF-β,mTOR, Hedgehog, and immunomodulatory signaling pathways, thus affecting biological processes, such as cellproliferation, apoptosis, cell cycle, migration, invasion, autophagy, EMT, angiogenesis, and chemoresistance andultimately exerting therapeutic effects on CRC (Tables 1 and 2). This evidence concerns the gene TP53 and colorectal carcinoma.