MAPK8 and colorectal carcinoma: Lee et al. [103] found that the expression of p-JNK and p-p38 MAPK was downregulated in HCT-116 cells after Geijigajakyak decoction (GJD) intervention, suggesting that GJD plays a role in anti-CRC invasion through JNK and p38 MAPK signaling pathways (Fig. 3).