TGFB1 and neoplasm: In addition, Pien Tze Huang could reverse tumor drug resistance by inhibiting the phosphorylation of N-cadherin, TGF-β, Smas2/3, and Smad 4 in tumor tissues while promoting the expression of E-cadherin, thereby inhibiting the movement, invasion, and EMT of CRC cells [196] (Fig. 7).