Several studies have demonstrated that the PI3K/Akt signaling pathway is aberrantly activated in many cancers, and that it is closely related to tumor cell proliferation, apoptosis, invasion, epithelial–mesenchymal transition (EMT), stem cell-like phenotype, and tumor drug resistance [40], in addition to being involved in tumor angiogenesis [41]. This evidence concerns the gene AKT1 and neoplasm.