Tao et al. [126] found that the Chinese herbal formula Weichang’an (WCA) dose-dependently upregulated rho GTPase activating protein 25 (ARHGAP25) expression in HCT-116 cells while downregulating the expression of MMP7, MMP9, zinc finger E-box binding homeobox 1 (ZEB1), and β-catenin, suggesting that inhibition of the Wnt/β-catenin signaling pathway is the mechanism by which WCA exerts its anti-CRC migratory and invasive effects in vitro. The gene discussed is MMP9; the disease is colorectal carcinoma.