TCF7L2 and colonic neoplasm: Pooja et al. [117] showed that emodin significantly inhibited the mRNA expression of CTNNB1 (β-catenin) and transcription factor-7-like-2 (TCF7L2) and the expression of cyclin D1, c-Myc, snail, vimentin, MMP2, and MMP9, the downstream targets of Wnt signaling in human colon cancer cells.