Yang et al. [120] found that GGC downregulated the Wnt/β-catenin signaling cascade and the expression of MMP2, MMP9, Wnt3a, β-catenin, and β-catenin downstream signals (Axin-1, p-GSK3β, and β-TrCP) and their target genes (c-myc, cyclin D1, and survivin) in HT-29 cells, suggesting that GGC may play a role in the anti-proliferation, anti-invasion, anti-migration and pro-apoptosis of CRC cells by targeting the Wnt/β-catenin signaling pathway. This evidence concerns the gene GGCT and colorectal carcinoma.