Dai et al. [49] found that EMD inhibited the expression of VEGFR2, PI3K and p-Akt in HCT-116 cells and tumor-bearing mice, suggesting that EMD may inhibit human CRC cell growth, adhesion and migration by suppressing VEGFR2/PI3K/Akt signaling pathway. The gene discussed is AKT1; the disease is colorectal carcinoma.