SOX2 and colorectal carcinoma: Wei et al. [148] found that the expression of stemness-related genes, such as Nanog, octamer-binding transcription factor 4, SRY-box transcription factor 2 (SOX2), aldehyde dehydrogenase 1, cluster of differentiation 133 (CD133), and B-lymphoma Mo-MLV insertion region 1 (Bmi-1), were significantly reduced in CRC cell lines after GA intervention.