Among the 10 known genes mapped by the mid-to-late aging-inverse regenerative DMRs, three genes are related to liver pathophysiology, including the epigenetic silencing of Duox1 by promoter hypermethylation in hepatocellular carcinoma (HCC) [46], Rap2c-mediated inactivation of pathological fibrosis [47], and the unique expression of a spliced variant of Rbbp7 in HCC [48] (Fig. 5A2, top). This evidence concerns the gene DUOX1 and hepatocellular carcinoma.