Consistent with suggestions that lifetime stress may be a clinically-relevant precipitant of AD and depressive pathologies, we previously showed that chronic stress and high levels of the main stress hormones, glucocorticoids, may trigger neuronal activation leading to accumulation of hyperphosphorylated Tau species in neurons by dysregulation of major degradative pathways such as the endolysosomal pathway and autophagy [45, 46]; both pathways are involved in sEV (e.g. exosome) biogenesis and secretion. This evidence concerns the gene MAPT and Alzheimer disease.