There are also other novel targets for diabetes mellitus control that could be exploited, such as GPCR 119 [13], GPER [14], 11β-hydroxysteroid dehydrogenase 1 [15], Vaspin [16], Metrnl [17], PEDF [18], Fetuin-A [19], ACRP 30(AdipoQ) [20], Visfatin, Melatonin [21], GIP [22], GPCR [23]. This evidence concerns the gene METRNL and diabetes mellitus.