The other factors which are also activated by the PEDF are the free fatty acid (FFA), toll-like receptor4(TLR4), nuclear factor kappa B (NFκB), suppressor of cytokine signalling (SOCS3),Janus kinase (JAK2) which also blocks the insulin receptor substrate which together contributes in the decreased insulin sensitivity and ultimately diabetes mellitus (Fig. 15). Here, INS is linked to diabetes mellitus.