ADIPOQ and obesity due to melanocortin 4 receptor deficiency: It is also revealed from a study that Acrp30 levels are found to be decreased in many models of obesity and diabetes [80] due to high levels of TNF-α [56], which shows that this protein is negatively linked with diabetes (Fig. 10) [57], also showed that the mice lacking Acrp30 shows insulin resistance [58] leading to the development of diabetes mellitus.