SERPINF1 and diabetes mellitus: The other factors which are also activated by the PEDF are the free fatty acid (FFA), toll-like receptor4(TLR4), nuclear factor kappa B (NFκB), suppressor of cytokine signalling (SOCS3),Janus kinase (JAK2) which also blocks the insulin receptor substrate which together contributes in the decreased insulin sensitivity and ultimately diabetes mellitus (Fig. 15).