IL10 and neoplasm: Inhibitory cytokines, such as TGF-β and IL-10, are secreted by Tregs in the TME, or cell contact-dependent protein pathways, such as programmed death-1 (PD-1), are activated and then inhibit the activation and function of T cells, which mediates the immune tolerance of T cells to PAAD-associated antigens so that tumor cells escape immune surveillance [7, 15].