Both the representative western blot bands (Fig. 1C) and the quantitative analyses (Fig. 1D) of ApoA-I and ApoB masses in sera of 3 healthy controls and 4 SCA patients show that ApoB level in SCA patients was much lower, although not statistically significant due to small sample size (3–4 samples), than that in healthy controls (p = 0.0731 in the left panel of Fig. 1D; a patient/control ratio of 0.723 ± 0.276 in the right panel of Fig. 1D) whereas ApoA-I level was similar (p = 0.8586 in left panel of Fig. 1D; a patient/control ratio of 0.997 ± 0.129 in the right panel of Fig. 1D). The gene discussed is APOA1; the disease is autosomal dominant cerebellar ataxia.