Previous findings have found that SPP1 shows high expression in many cancers and can be used to predict patient prognosis, including ovarian cancer, glioblastoma, hepatocellular carcinoma and gastric cancer [41–43], but no studies have been shown to explore the relevance of SPP1 to LUAD,therefore our study may prove to SPP1 in LUAD and its potential clinical value. This evidence concerns the gene SPP1 and hepatocellular carcinoma.