In the OPERA® cohort, the 2277 PLWH identified as HTE on December 31, 2016 tended to be older, had higher VLs, lower CD4 cell counts as well as a higher burden of ADEs, concomitant medications and non-ADE morbid conditions than the 21,906 non-HTE PLWH. The gene discussed is CD4; the disease is acute disseminated encephalomyelitis.