However, after adjusting for age, CD4 count, and prior ADEs, HTE status was no longer associated with the development of a new ADE (aIRR 1.44, 95% CI 0.86, 2.40) or new non-ADE morbidity (aIRR 0.96, 95% CI 0.74, 1.25) [10]. This evidence concerns the gene CD4 and acute disseminated encephalomyelitis.