Interestingly, MYT1L levels decrease during aging in both mice and humans (Supplementary Fig. S1A), and loss of neuronal cell identity has recently been suggested to play a role in Alzheimer’s disease models [75, 76], which suggests that neurodegeneration could also be regulated by the novel MYT1L-mediated mechanism presented here. The gene discussed is MYT1L; the disease is early-onset autosomal dominant Alzheimer disease.