STING1 and obesity due to melanocortin 4 receptor deficiency: To define a role of STING in the lung inflammation in obesity, as it currently is not feasible in manipulating signaling pathways in patients, we developed and utilized a high-fat diet (HFD)-induced obese (DIO) mouse model, which were classified following the published criteria including the greater body weight gains in DIO mice compared to controls (Fig. 1c).