To investigate the association between the gut inflammatory response and stroke brain volumetric changes, protein levels of TNF-α, TNFR1, phosphorylated IkBα, gut tight junction proteins, and binding activity of NF-kB P65 at 12 weeks PT were correlated with MRI lesion volume and midline shift results at 12 weeks PT (Fig. 4). The gene discussed is TNFRSF1A; the disease is Stroke.