SHLD1 and major depressive disorder: RP11-349A22.5 in the blue module and C20orf196 in the midnightblue module were identified as hub gene having high connectivity with nodes in a module and these two hub genes have been shown to have a key function in differentiating suicide without depression while MAPK8IP3 in the pink module and RP11-697N18.2 in the orange module were found to be hub genes in the module significantly associated with depression without suicide (Supplementary Fig. 3).