To identify AD-associated cellular components in oligodendrocytes, transcriptome profiling was conducted at the single-cell level via single-cell RNA sequencing using 1-, 3-, and 6-month-old wild-type (WT) and App KI mice (AppNL-G-F) harboring the Swedish and Beyreuther/Iberian and Arctic mutations in the App gene locus22. This evidence concerns the gene APP and Alzheimer disease.