MAPK1 and Alzheimer disease: In particular, we found significant alternations in the transcriptional profiles between DAOs and MOL 3/4 clusters and GO-term of up-regulated genes in DAO versus MOL3/4 showed the interleukin & chemokine production and ERK signaling (Fig. 3a and c), which was also confirmed during the disease progression in AD mice brain (Supplementary Fig. 11a, b).