According to the above research results, FTO, HNRNPC, RBMX, ELAVL1, YTHDC1, LRPPRC, YTHDF2, HNRNPA2B1, IGFBP2 and RBM15B were the 10 most important genes and were included in the construction of the sepsis nomogram. The gene discussed is YTHDF2; the disease is Sepsis.