We found that the expression of METTL3, METTL14, RBM15, RBM15B, CBLL1, YTHCD1, YTHDC2, YTHDF1, YTHDF2, YTHDF3, HNRNPC, LRPPRC, HNRNPA2B1, RBMX, ELAVL1 and FTO was significantly lower in the patients with sepsis, while IGFBP2 expression was significantly higher in the patients with sepsis. The gene discussed is IGFBP2; the disease is Sepsis.