MAPK1 and esophageal squamous cell carcinoma: As well as correlation analysis showing ROCK1 and MAPK1 positively correlated in ESCC (Fig. 2I), further evidences including target prediction, kinase activity analysis, molecular docking and pull-down assays suggested that dasabuvir bound to and inhibited ROCK1 activity (Fig. 2G–H, Fig. 3).