ROCK1 and cancer: ROCK1/2 inhibitors such as fasudil [40, 41], AT13148 [42–44], Y-27632 [45, 46], YM529/ONO-5920 [47, 48], PT-262 [49], WF-536 [50–52] and RKI-1447 [53] have shown significant cancer inhibition [13].