We next proved that in vitro co-culture of the ex vivo F4/80+TAMs with the endothelial cells (SVEC4–10) under tumor-cell conditioned media (TCM) greatly stimulated the expression of a few key angiogenic markers including CD31, CD34, TIE2, VEGFA, Ki67, etc. (Fig. 5B). Here, PECAM1 is linked to neoplasm.