CD34 and neoplasm: In IHC data, whereas F4/80+ staining was strong within the tumors in the control (Supplementary Fig. S5A the upper channel) and treatment-resistant mice (CL-NS, Supplementary Fig. S5A the bottom channel), the staining was only minimal in effectively CL-treated mice (Supplementary Fig. S5A the middle channels), whose tumor also showed greatly reduced CD146+ or CD34+ staining (Supplementary Fig. S5A, B).