NPPC and postural orthostatic tachycardia syndrome: To predict whether high sympathetic activity exists among pediatric POTS before treatment, the investigators showed that the pre-treatment plasma norepinephrine levels [7], copeptin levels [8], C-type natriuretic peptide levels [9], baseline values of pre-treatment 24-hour heart rate variability [10], QTcd [11], and heart rate variation [12] during head-up tilt testing (HUTT) had a specific predictive value for the effectiveness of metoprolol in treating POTS.