SOX1 and Lambert-Eaton myasthenic syndrome: Though P/Q-type calcium channel antibody is a general biomarker for LEMS, coexisting antiglial/neuronal nuclear antibody (AGNA, or Sry-like high-mobility group box protein 1 [SOX-1]-IgG) or ANNA-1 positivity is more predictive of small cell carcinoma in those cases [76].