Proportion of PD-1 positive CD8 T-cells normalized to tumor cell count was highly positively correlated with cytolytic activity (granzyme-B positivity), r(347) = 0.714, p < 0.001, and activation/proliferation (Ki67 positivity), r(347) = 0.798, p < 0.001 (Supplementary Table 2). Here, GZMB is linked to neoplasm.