For lung, RAI3 overexpression resulted in reduced cell growth in NSCLC cell line H1792 (Xu et al. 2005), GPRCA5-knockout mice developed spontaneous lung tumors (Tao et al. 2007) and loss of heterozygosity of chromosome 12p, where GPRC5A gene resides has been frequently detected in human NSCLCs (Takeuchi et al. 1996; Grepmeier et al. 2005). Here, GPRC5A is linked to non-small cell lung carcinoma.