PLVAP and Protein-losing enteropathy: Additionally, it was shown that PLVAP knockout mice survived postnatally up to 4 weeks or survived up to 3–4 months, respectively, but suffered from growth retardation, anemia, and selective leakage of plasma proteins into the interstitium with subsequent edema and dyslipidemia, eventually leading to a lethal, protein-losing enteropathy (Herrnberger et al. 2012; Rantakari et al. 2015; Stan et al. 2012).