Considering its association with cancer, traumatic spinal cord injury, transplant glomerulopathy (TG), ischemic brain disease and ocular disease, PLVAP is also investigated as novel therapeutical target, e.g. during cancer therapy (Klaassen et al. 2009; Mozer et al. 2010; Schafer et al. 2009; Wang et al. 2014; Wisniewska-Kruk et al. 2012, 2014; Yamamoto et al. 2007). The gene discussed is PLVAP; the disease is brain ischemia.