As result, the patients suffered from similar phenotypes as observed in the PLVAP-knockout mice; severe protein-losing enteropathy, characterized by excessive loss of plasma proteins in the gastrointestinal tract, a severe pathological condition that can eventually lead to death (Broekaert et al. 2018; Elkadri et al. 2015). This evidence concerns the gene PLVAP and Protein-losing enteropathy.