That suggestion is supported by the recent findings that (i) the brain of a deceased Alzheimer’s disease subject contained numerous forms of tau differing in their extent of phosphorylation, seeding ability, and resistance to protease (58) and (ii) populations of tau isolated from different Alzheimer’s disease individuals differed in their kinetics of seeding (59). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.