Our data suggest two main findings; first, that hiPSC-derived MGL and NPC cells show clear differences in IL6Ra signaling capabilities and second, that exposure of MGLs to IL-6 recapitulates molecular and functional phenotypes of relevance for psychiatric disorders, particularly schizophrenia, consistent with evidence from genetic (Perry et al., 2021), blood biomarker (Allswede et al., 2020) and animal models (Smith et al., 2007) that link this cytokine with increased risk for schizophrenia. The gene discussed is IL6; the disease is schizophrenia.