The frequent occurrence of t(4;14), t(14;16), t(14;20), MYC translocations in double-hit MM, and t(4;14), t(14;16), and MYC translocations in triple-hit MM indicates that t(14;16), t(14;20), and MYC translocations are high-risk translocations. The gene discussed is MYC; the disease is Miyoshi myopathy.