SMAD4 and neoplasm: APC, PDGFRA, RET, and SMO are tumor-related genes; ATM, CDKN2A, RB1, NOTCH1, SMAD4, SMARCB1, and TP53 are tumor suppressor genes; EGFR, ERBB2, MET, and MPL are proliferation-related genes; and FGFR2 and FGFR3 are related to the tumor microenvironment.