ERBB4 and NPM1 alterations were equally frequent, whereas APC, ATM, CDKN2A, EGFR, ERBB2, FGFR2, FGFR3, MET, MPL, NOTCH1, PDGFRA, RB1, RET, SMAD4, SMARCB1, SMO, and TP53 alterations were more frequent in cSCC+ than in cSCC- cases. This evidence concerns the gene SMARCB1 and skin squamous cell carcinoma.