Complementary studies in control and HLA-G-depleted parental lung and melanoma BMICs showed that HLA-G ablation resulted in reduced p-STAT3 levels in lung and melanoma BMICs when compared to their control counterparts (Fig. 3B), demonstrating a bona fide role for HLA-G in STAT3 signaling activation in BMICs. This evidence concerns the gene HLA-G and melanoma.