Intriguingly, suppression of STAT3 signaling with DR-1-55 in HLA-G OE BMICs (SI Appendix, Fig. S10C) caused a drastic decline in the secondary sphere formation of HLA-G OE lung and melanoma BMICs despite the presence of high HLA-G levels in these cells (Fig. 3C). Here, STAT3 is linked to melanoma.