HLA-G and brain neoplasm: We also saw a significant reduction in brain tumor lesions formed by HLA-G OE lung and melanoma BMICs upon STAT3 signaling inhibition ex vivo (Fig. 3 D,  i–iii; P = 0.002; Fig. 3 D,  iv–vi; P = 0.005) despite the overexpressed HLA-G levels in these cells.