In support of these results, other studies have observed a positive relationship between HLA-G and its established protein partners—ILT2, ILT4, and KIR2DL4 (46) where HLA-G has been shown to particularly up-regulate ILT4 expression in tumor cells when stimulating cell signaling pathways (33, 47). The gene discussed is KIR2DL4; the disease is neoplasm.