We noted that HLA-G loss attenuated the ability of lung and melanoma BMICs to form macrometastatic brain lesions compared to the large tumors formed by their time-matched controls (Fig. 2 E, i and ii, n = 5, P = 0.0003 and Fig. 2 E, iii and iv, n = 3, P = 0.049; Fig. 2 F, i and ii, n = 3; P = 0.02 and Fig. 2 F, iii and iv, n = 4; P = 0.0002, respectively). This evidence concerns the gene HLA-G and melanoma.