To determine whether HLA-G promotes BMIC self-renewal and growth in the brain through STAT3 signaling, we inhibited STAT3 signaling in HLA-G OE lung and melanoma BMICs with the STAT3 inhibitory drug DR-1-55 (42) (See SI Appendix, Fig. S10 A and B for IC50 values). Here, HLA-G is linked to melanoma.